The C-terminal region of the non-structural protein 2B from Hepatitis A Virus demonstrates lipid-specific viroporin-like activity. Scientific Reports. October 2015

Hepatitis A Virus (HAV) spreads through contaminated food or water and causes acute liver disease, sometimes resulting in liver failure. While developing countries with poor sanitary conditions have high levels of HAV infection, developed countries occasionally have large outbreaks. Understanding the molecular mechanism of HAV infection is necessary to devise strategies for prevention and cure.

In this work, Shukla and colleagues from IIT-Delhi attempt to unravel the molecular mechanism of HAV replication. They show that a non-structural protein 2B from HAV acts as a viroporin, that is, a viral protein which interacts with cellular membranes to enhance viral replication. 2B can be a possible target molecule for devising inhibitors against HAV infection.

Sponsoring Organization: 

Department of Biotechnology (DBT)

Contact details: 

Manidipa Banerjee

School of Biological Sciences