Research Cafe: Tackling antimicrobial resistance (AMR) via nanotheranostic interventions

As part of the Research Café series on April 25, Prof Shalini Gupta of Chemical Engineering Department spoke at length on the topic Tackling Antimicrobial Resistance via Nanotheranostic Interventions.

The inter-disciplinary Seminar series that started on March 10 last year, is aimed at understanding the science behind some special research that is being done in IIT Delhi.

After spelling out an overview of her research group, she gave a brief about the challenges due to Antimicrobial resistant pathogens and different solutions from her group.

Her talk broadlyfocused on two aspects--Translation study for point of care (POC) assay development for sepsis management and Proof-of-concept study on electric field-driven rapid diagnosis.

The rapid rise of antimicrobial resistance (AMR) has emerged as a serious global threat to human health. AMR results when an improper antibiotic treatment leads to wiping out of non-resistant bacteria, leaving the resistant cells to thrive. One of the ways through which AMR can be tackled is by rational design of rapid diagnostic tools that allow early detection of the underlying medical condition.

Prof Shalini described a diagnostic platform called SetifloTM that has been developed for rapid bedside diagnosis of septicemia. It can identify the Gram status of bacteremia < 10 min from a drop of human plasma.

She alsoillustrated some preliminary work inher group on using impedance spectroscopy as a diagnostic technique.